Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 6
MIP-3 beta Antibody (MA5-23833) in ICC/IF
Immunocytochemistry analysis of MIP-3 beta in immersion fixed human peripheral blood mononuclear cells (PBMCs). Samples were incubated in MIP-3 beta monoclonal antibody (Product # MA5-23833) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red) and counterstained with DAPI (blue).
产品信息
MA5-23833
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
54909
抗原
E. coli-derived recombinant human CCL19/MIP-3 beta Gly22-Ser98
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein A/G
保存液
600mM tris, 500mM acetic acid
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2605835
靶标信息
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC- subfamily of chemokines. It is most closely related to CCL21, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: beta chemokine exodus-3; Beta-chemokine exodus-3; C-C motif chemokine; C-C motif chemokine 19; CC chemokine ligand 19; chemokine (C-C motif) ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; M-MIP-3-beta; Macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MIP-3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; Small-inducible cytokine A19
基因别名: CCL19; CKb11; ELC; MIP-3b; MIP3B; SCYA19
UniProt ID: (Human) Q99731
Entrez Gene ID: (Human) 6363
establishment of T cell polarity
immunological synapse formation
dendritic cell chemotaxis
myeloid dendritic cell chemotaxis
monocyte chemotaxis
positive regulation of dendritic cell antigen processing and presentation
cellular calcium ion homeostasis
inflammatory response
immune response
cell communication
G-protein coupled receptor signaling pathway
activation of JUN kinase activity
response to virus
positive regulation of glycoprotein biosynthetic process
T cell costimulation
positive regulation of interleukin-12 production
positive regulation of tumor necrosis factor production
response to prostaglandin E
positive regulation of T cell proliferation
positive regulation of NF-kappaB import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of T-helper 1 cell differentiation
positive regulation of endocytosis
positive regulation of protein kinase activity
positive regulation of JNK cascade
lymphocyte chemotaxis
positive regulation of receptor-mediated endocytosis
cell maturation
positive regulation of interleukin-1 beta secretion
positive regulation of chemotaxis
release of sequestered calcium ion into cytosol
positive regulation of protein kinase B signaling
regulation of cell projection assembly
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
response to nitric oxide
interleukin-12 secretion
positive regulation of neutrophil chemotaxis
mature conventional dendritic cell differentiation
cellular response to virus
negative regulation of leukocyte apoptotic process
positive regulation of cell motility
positive regulation of dendritic cell dendrite assembly
