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Immunogen sequence: QVLQQVDNK FIACLMSTKT EENGEADSYE KQQAQGSGRK KLLSSTLIPP LEITVTEEQR RLLWCYHKNL EDLGLEFVFP DTSDSLVLVG KVPLCFVERE ANELRRGRST VTKSIVEEFI REQLELLQTT GGIQGTLPLT VQKVLASQAC HGAIKFNDGL SLQESCRLIE ALSSCQLPFQ CAHGRPSMLP LADIDHLEQE KQIKPNLTKL RKMAQAWRLF GKAECDTRQS LQQSMPPCEP P (1190-1430 aa encoded by BC112167)
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DNA mismatch repair protein Mlh3; MGC138372; MutL protein homolog 3
基因别名: HNPCC7; MLH3
UniProt ID: (Human) Q9UHC1
Entrez Gene ID: (Human) 27030
分子生物学功能:
DNA metabolism protein