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产品信息
BS-2992R-A594
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human MLK3
偶联物
激发/发射光谱
590/618 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
MAP3K11 (MLK3) is a serine/threonine kinase that activates both the p38 MAP kinase and c-Jun kinase pathways. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAP3K11; MGC17114; mitogen activated protein kinase kinase kinase 11; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; Src-homology 3 domain-containing proline-rich kinase
基因别名: 2610017K16Rik; MAP3K11; MEKK11; MLK-3; MLK3; PTK1; RHOE; SPRK
UniProt ID: (Human) Q16584, (Rat) Q66HA1, (Mouse) Q80XI6
Entrez Gene ID: (Human) 4296, (Rat) 309168, (Mouse) 26403
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
protein binding
ATP binding
mitogen-activated protein kinase kinase binding
mitogen-activated protein kinase kinase kinase binding
identical protein binding
protein homodimerization activity
Rac GTPase binding
MAP kinase kinase kinase activity
protein tyrosine kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
activation of MAPK activity
protein phosphorylation
microtubule-based process
JNK cascade
activation of JNKK activity
activation of JUN kinase activity
cell death
cell proliferation
positive regulation of JUN kinase activity
positive regulation of neuron apoptotic process
positive regulation of JNK cascade
protein autophosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of apoptotic process
phosphorylation
