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MLL1 Antibody (A300-374A) in WB
Detection of human MLL1 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, 293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-MLL1 antibody A300-374A (lot A300-374A-5) used for WB at 0.1 µg/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
产品信息
A300-374A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residues 2725 and 2775 of human myeloid/lymphoid or mixed-lineage leukemia 1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
靶标信息
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALL-1; CDK6/MLL fusion protein; CXXC-type zinc finger protein 7; Cysteine methyltransferase KMT2A; Histone-lysine N-methyltransferase 2A; lysine (K)-specific methyltransferase 2A; Lysine N-methyltransferase 2A; mixed lineage leukemia 1; MLL-AF4 der(11) fusion protein; MLL/ENL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL/hCDCrel fusion protein; Myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Myeloid/lymphoid or mixed-lineage leukemia protein 1; rearranged MLL protein; Trithorax-like protein; Zinc finger protein HRX
基因别名: ALL-1; ALL1; CXXC7; HRX; HTRX; HTRX1; KMT2A; MLL; MLL-AF9; MLL/GAS7; MLL1; MLL1A; TET1-MLL; TRX1; WDSTS
UniProt ID: (Human) Q03164
Entrez Gene ID: (Human) 4297
core promoter sequence-specific DNA binding
AT DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H3-K4 specific)
identical protein binding
protein homodimerization activity
transcription regulatory region DNA binding
unmethylated CpG binding
lysine-acetylated histone binding
histone modifying enzyme
DNA methylation
transcription from RNA polymerase II promoter
protein complex assembly
apoptotic process
negative regulation of cell proliferation
visual learning
post-embryonic development
anterior/posterior pattern specification
peptidyl-lysine monomethylation
positive regulation of transporter activity
circadian regulation of gene expression
embryonic hemopoiesis
exploration behavior
response to potassium ion
histone H4-K16 acetylation
histone H3-K4 dimethylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of short-term neuronal synaptic plasticity
spleen development
homeostasis of number of cells within a tissue
histone H3-K4 methylation
positive regulation of histone H3-K4 methylation
membrane depolarization
definitive hemopoiesis
regulation of histone H3-K14 acetylation
histone H3-K4 trimethylation
regulation of histone H3-K27 acetylation
regulation of histone H3-K9 acetylation
positive regulation of cellular response to drug
