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Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Raji, mouse brain.
Predicted reactivity: Mouse (85%), Rat (86%), Pig (91%), Rhesus Monkey (97%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The exact function of the MMACHC protein is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Alkylcobalamin:glutathione S-alkyltransferase; CblC; Cyanocobalamin reductase (cyanide-eliminating); Cyanocobalamin reductase / alkylcobalamin dealkylase; Methylmalonic aciduria and homocystinuria type C protein; methylmalonic aciduria and homocystinuria type C protein homolog; MMACHC; RP11-291L19.3
基因别名: 1810037K07Rik; cblC; MMACHC
UniProt ID: (Human) Q9Y4U1, (Mouse) Q9CZD0
Entrez Gene ID: (Human) 25974, (Mouse) 67096