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MMP19 Antibody (PA5-28213) in IHC (P)
MMP19 Polyclonal Antibody detects MMP19 protein at cytosol on human hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded human hepatoma. MMP19 Polyclonal Antibody (Product # PA5-28213) dilution: 1:500. Scale bar = 100 µm. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-28213
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 214 and 489 of Human MMP19
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545689
产品详细信息
Recommended positive controls: MMP19-transfected 293T.
Predicted reactivity: Rat (81%), Bovine (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: matrix metallo protease; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; Matrix metalloproteinase-19; matrix metalloproteinase-beta19; MMP; MMP-18; MMP-19; MMPs
基因别名: CODA; MMP18; MMP19; RASI; RASI-1
UniProt ID: (Human) Q99542
Entrez Gene ID: (Human) 4327
