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Immunogen sequence: SPRPARLHRF WEGLPAQVRV VQAAYARHRD GRILLFSGPQ FWVFQDRQLE GGARPLTELG LPPGEEVDAV FSWPQNGKTY LVRGRQYWRY DEAAARPDPG YPRDLSLWEG APPSPDDVTV SNAGDTYFFK GAHYWRFPKN SIKTEPDAPQ PMGPNWLDCP APSSGPRAPR PPKATPVSET CDCQCELNQA A
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Leukolysin; matrix metallo protease; matrix metallopeptidase 25; matrix metallopeptidase-like 1; matrix metalloproteinase 20; matrix metalloproteinase 25; Matrix metalloproteinase-25; matrix metalloproteinase-like 1; membrane-type 6 matrix metalloproteinase; Membrane-type matrix metalloproteinase 6; Membrane-type-6 matrix metalloproteinase; MMP; MMP 25; MMP-25; MMPs; MT MMP 6; MT-MMP 6; MT6 MMP; MT6-MMP
基因别名: F730048C11Rik; Leukolysin; MMP-25; MMP20; MMP20A; MMP25; MMPL1; MT-MMP 6; MT-MMP6; MT6-MMP; MT6MMP; MTMMP6
UniProt ID: (Human) Q9NPA2, (Mouse) Q3U435
Entrez Gene ID: (Human) 64386, (Rat) 302963, (Mouse) 240047