Proteintech

MMP28 Polyclonal Antibody

MMP28 Antibody in Immunocytochemistry (ICC/IF)

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MMP28 Antibody (18237-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed A549 cells using 18237-1-AP (MMP28 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

MMP28 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

18237-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

查看5篇已发表文章 5篇已发表文章

免疫组化 (IHC)

查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:10-1:100

查看3篇已发表文章 3篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

MMP28 Fusion Protein Ag12980 (194-393 aa encoded by BC002631)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.13 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody is specific to MMP28.

Immunogen sequence: LGNAFDGPG GALAHAFLPR RGEAHFDQDE RWSLSRRRGR NLFVVLAHEI GHTLGLTHSP APRALMAPYY KRLGRDALLS WDDVLAVQSL YGKPLGGSVA VQLPGKLFTD FETWDSYSPQ GRRPETQGPK YCHSSFDAIT VDRQQQLYIF KGSHFWEVAA DGNVSEPRPL QERWVGLPPN IEAAAVSLND GDFYFFKVQS V (194-393 aa encoded by BC002631)

靶标信息

Epilysin, also known as matrix metalloproteinase-28 (MMP-28), is a secreted protein that belongs to the peptidase M10A family. Matrix metalloproteinase proteins are responsible for the breakdown of the extracellular matrix which is important for normal physiological processes such as tissue remodeling, reproduction and embryonic development. Epilysin is produced by proliferating keratinocytes and is responsible for mediating the degradation of casein. Its expression is upregulated in response to injury of the skin suggesting that Epilysin may be involved in tissue repair and homeostasis. In addition, Epilysin may function predominantly in the nervous system. Incubation of Epilysin with rat embryonic brain tissue results in the degradation of myelin proteins. In Xenopus, Epilysin localizes to nerves and is upregulated during neurulation. This suggests that Epilysin plays an evolutionarily conserved role in neural development and may be involved in modulating the axonal-glial extracellular environment.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Epilysin; matrix metallo protease; matrix metallopeptidase 28 (epilysin); matrix metalloprotease MMP25; matrix metalloproteinase 28 (epilysin); Matrix metalloproteinase-28; MMP; MMP-28; MMPs; PRO4339; UNQ1893

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基因别名: D130023P12; EPILYSIN; MM28; MMP-25; MMP-28; MMP25; MMP28; UNQ1893/PRO4339

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UniProt ID: (Human) Q96TE2

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Entrez Gene ID: (Human) 79148, (Rat) 303384, (Mouse) 118453

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功能

metalloendopeptidase activity calcium ion binding zinc ion binding metalloprotease

参与通路

proteolysis negative regulation of macrophage chemotaxis