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Immunogen sequence: FLDGNVSFL PENSFPSRFQ PFQDGSSGQR RLIALLMAFV CSLPRNVEIP QLNQLMRELL ELSCCHSCPF SSTAAAKCFA GLLNKHPAGQ QLDEFLQLAV DKVEAGLDSG PCRSQAFTLL LWVTKALVLR YHPLSSCLTA RLMGLLSDPE LGPAAADGFS LLMSDCTDVL TRAGHAEVRI MFRQRFFTDN VPALVQGFHA APQDVKPNYL KGLSHVLNRL PKPVLLPELP TLLSLLLEAL SCPDCVVQLS TLSCLQPLLL EAPQVMSLHV DTLVTKFLNL SSSPSMAVRI AALQCMHALT RLPTPVLLPY KPQVIRALAK PLDDKKRLVR KEAVSARGEW FLLGSPGS (457-803 aa encoded by BC006575)
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: hMMS19; homolog of yeast MMS19; incisor protein; MET18 homolog; MMS19 cytosolic iron-sulfur assembly component; MMS19 nucleotide excision repair homolog; MMS19 nucleotide excision repair protein homolog; MMS19 nucleotide excision repair-like; MMS19-like (MET18 homolog, S. cerevisiae); MMS19-like protein
基因别名: 2410001K24Rik; 2610042O15Rik; AI316855; C79368; C86341; hMMS19; MET18; MMS19; MMS19L
UniProt ID: (Human) Q96T76, (Mouse) Q9D071
Entrez Gene ID: (Human) 64210, (Rat) 171124, (Mouse) 72199
分子生物学功能:
scaffold/adaptor protein