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Application
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MRC2 Antibody (PA5-104512) in ICC/IF
Immunocytochemistry analysis of MRC2 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with MRC2 polyclonal antibody (Product # PA5-104512) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-104512
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MRC2(Accession Q9UBG0), corresponding to amino acid residues T125-V175.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2853813
产品详细信息
Antibody detects endogenous levels of total MRC2.
靶标信息
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-type lectin domain family 13 member E; C-type mannose receptor 2; CD280; collagen-binding factor Endo180; endocytic receptor (macrophage mannose receptor family); Endocytic receptor 180; Lectin lambda; Macrophage mannose receptor 2; mannose receptor, C type 2; novel lectin; UPAR-associated protein; Urokinase-type plasminogen activator receptor-associated protein
基因别名: CD280; CLEC13E; ENDO180; KIAA0709; mKIAA0709; MRC2; UPARAP
UniProt ID: (Human) Q9UBG0, (Rat) Q4TU93, (Mouse) Q64449
Entrez Gene ID: (Human) 9902, (Rat) 498011, (Mouse) 17534
