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Invitrogen
MRE11 Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
产品信息
PA3-16527
应用
建议稀释比
已发表文章
产品规格
种属反应
Chicken,
Hamster,
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Human Mre11 full length.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2145113
产品详细信息
This Mre11 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections (PMID 21279473) Immunoprecipitation and Western Blot.
In WB, a band can be seen at ~81 kDa.
For ICC/IF, this antibody has been used with methanol-fixed IMR90 primary human fibroblasts. For IP, the suggested working dilution is 3 µL for immunoprecipitation of 3X10^6 cells.
Co-IP application has been reported by Ching et al 2012 (PMID: 22190719).
Suggested positive control: antigen standard for MRE11A (transient overexpression lysate), Hela whole cell extract, Hela whole cell lysate.
靶标信息
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AT-like disease; DNA recombination and repair protein; Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; endo/exonuclease Mre11; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; mmMRE11A; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); MRE11 meiotic recombination 11-like protein A
基因别名: ATLD; HNGS1; MRE11; MRE11A; MRE11B
UniProt ID: (Chicken) Q9IAM7, (Human) P49959, (Rat) Q9JIM0, (Mouse) Q61216
Entrez Gene ID: (Chicken) 395555, (Human) 4361, (Rat) 64046, (Chinese hamster) 100750877, (Mouse) 17535
single-stranded DNA endodeoxyribonuclease activity
5'-3' exonuclease activity
manganese ion binding
DNA binding
double-stranded DNA binding
ATP-dependent DNA helicase activity
nuclease activity
endodeoxyribonuclease activity
protein binding
protein C-terminus binding
3'-5' exonuclease activity
cadherin binding involved in cell-cell adhesion
endonuclease activity
exonuclease activity
hydrolase activity
regulation of mitotic recombination
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA replication
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
sister chromatid cohesion
mitotic G2 DNA damage checkpoint
synapsis
reciprocal meiotic recombination
heart development
cell proliferation
viral process
intra-S DNA damage checkpoint
telomeric 3' overhang formation
positive regulation of protein autophosphorylation
positive regulation of telomere maintenance
positive regulation of type I interferon production
DNA duplex unwinding
negative regulation of DNA endoreduplication
positive regulation of kinase activity
negative regulation of apoptotic process
negative regulation of viral entry into host cell
nucleic acid phosphodiester bond hydrolysis
cell-cell adhesion
regulation of signal transduction by p53 class mediator
telomere maintenance
base-excision repair
nucleotide-excision repair
chromosome organization
meiotic cell cycle
meiotic DNA double-strand break formation
mitochondrial double-strand break repair via homologous recombination
DNA strand resection involved in replication fork processing
DNA metabolic process
