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Invitrogen
MRP1 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
图: 1 / 4
MRP1 Antibody (PA5-114802) in ICC/IF
Immunofluorescence analysis of ABCC1 was performed using 70% confluent log phase A549 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with MRP1 Polyclonal Antibody (Product # PA5-114802) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32790), (1:2... View More
产品信息
PA5-114802
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ABCC1(Accession P33527), corresponding to amino acid residues M1-V39.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899438
产品详细信息
Antibody detects endogenous levels of total ABCC1.
靶标信息
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette sub-family C member 1; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; DKFZp686N04233; DKFZp781G125; Glutathione-S-conjugate-translocating ATPase ABCC1; leuk; Leukotriene C(4) transporter; LTC4 transporter; multidrug resistance protein 1; Multidrug resistance-associated protein 1; multiple drug resistance-associated protein
基因别名: ABC29; ABCC; ABCC1; Abcc1a; Abcc1b; Avcc1a; GS-X; Mdrap; MRP; MRP1
UniProt ID: (Human) P33527, (Rat) Q8CG09, (Mouse) O35379
Entrez Gene ID: (Human) 4363, (Rat) 24565, (Mouse) 17250
transporter activity
ATP binding
cobalamin-transporting ATPase activity
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
anion transmembrane-transporting ATPase activity
long-chain fatty acid transporter activity
xenobiotic-transporting ATPase activity
drug transmembrane transporter activity
glutathione S-conjugate-exporting ATPase activity
efflux transmembrane transporter activity
oxidoreductase activity
lipid-transporting ATPase activity
glutathione transmembrane transporter activity
sphingolipid transporter activity
nucleotide binding
hydrolase activity
ATP-binding cassette (ABC) transporter
leukotriene metabolic process
transport
cobalamin metabolic process
cobalamin transport
vitamin transmembrane transport
response to drug
transmembrane transport
anion transmembrane transport
drug transmembrane transport
response to oxidative stress
plasma membrane long-chain fatty acid transport
positive regulation of cell migration
phospholipid efflux
glutathione transmembrane transport
xenobiotic transport
daunorubicin transport
drug export
oxidation-reduction process
cell chemotaxis
negative regulation of neuron death
