Proteintech

MRP1 Monoclonal Antibody (1G4A2)

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MRP1 Antibody (67228-1-IG) in WB

Non-boil and boiled HepG2 and A549 cell lysates were subjected to SDS PAGE followed by western blot with 67228-1-Ig (ABCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. Left panel was exposed for 20 sec. and right panel was exposed for 1 min.

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产品信息

67228-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:10,000

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免疫组化 (IHC)

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产品规格

种属反应

Human

已发表种属

Not Applicable

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1G4A2

抗原

ABCC1 Fusion Protein Ag27048

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1000 µg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Aliquoting is unnecessary for -20°C storage.

靶标信息

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ATP-binding cassette sub-family C member 1; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; DKFZp686N04233; DKFZp781G125; Glutathione-S-conjugate-translocating ATPase ABCC1; leuk; Leukotriene C(4) transporter; LTC4 transporter; Multidrug resistance-associated protein 1

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基因别名: ABC29; ABCC; ABCC1; GS-X; MRP; MRP1

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UniProt ID: (Human) P33527

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Entrez Gene ID: (Human) 4363

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功能

transporter activity ATP binding cobalamin-transporting ATPase activity ATPase activity ATPase activity, coupled to transmembrane movement of substances anion transmembrane-transporting ATPase activity ATP-binding cassette (ABC) transporter

参与通路

leukotriene metabolic process transport cobalamin metabolic process cobalamin transport vitamin transmembrane transport response to drug transmembrane transport anion transmembrane transport