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NeoBiotechnologies
MSH6 (DNA Mismatch Repair Protein) Recombinant Rabbit Monoclonal Antibody (MSH6/6654R)
产品信息
2956-RBM14-P0
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Cat,
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MSH6/6654R
抗原
Recombinant fragment (around aa 1-200) of human MSH6 protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; hMSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS protein homolog 6; MutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein; sperm-associated protein
基因别名: GTBP; GTMBP; HNPCC5; HSAP; MSH6; p160
UniProt ID: (Human) P52701
Entrez Gene ID: (Dog) 474585, (Human) 2956
magnesium ion binding
four-way junction DNA binding
chromatin binding
double-stranded DNA binding
protein binding
ATP binding
ATPase activity
mismatched DNA binding
guanine/thymine mispair binding
single guanine insertion binding
single thymine insertion binding
oxidized purine DNA binding
MutLalpha complex binding
methylated histone binding
protein homodimerization activity
ADP binding
DNA metabolism protein
meiotic mismatch repair
DNA repair
mismatch repair
reciprocal meiotic recombination
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
viral process
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
isotype switching
positive regulation of isotype switching
negative regulation of DNA recombination
positive regulation of helicase activity
intrinsic apoptotic signaling pathway
