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Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: DWQCPRTPYA ASRDFDVKYV VPSFSAGGLV QAMVTYEGDR NESAVFVAIR NRLHVLGPDL KSVQSLATGP AGDPGCQTCA ACGPGPHGPP GDTDTKVLVL
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: c-met-related tyrosine kinase; CD136; CDw136; Macrophage-stimulating protein receptor; MSP receptor; MST1R variant RON30; MST1R variant RON62; p185-Ron; Protein-tyrosine kinase 8; PTK8 protein tyrosine kinase 8; RON variant E2E3
基因别名: CD136; CDw136; MST1R; PTK8; RON
UniProt ID: (Human) Q04912
Entrez Gene ID: (Human) 4486
分子生物学功能:
transmembrane signal receptor