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产品信息
H00022823-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MTF2 (AAH10013.1, 1 a.a. approximately 536 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRDSTGAGNS LVHKRSPLRR NQKTPTSLTK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV ICDKCGQGYH QLCHTPHIDS SVIDSDEKWL CRQCVFATTT KRGGALKKGP NAKALQVMKQ TLPYSVADLE WDAGHKTNVQ QCYCYCGGPG DWYLKMLQCC KCKQWFHEAC VQCLQKPMLF GDRFYTFICS VCSSGPEYLK RLPLQWVDIA HLCLYNLSVI HKKKYFDSEL ELMTYINENW DRLHPGELAD TPKSERYEHV LEALNDYKTM EVSNGIEKKG KKKSVGRPPG PYTRKMIQKT AEPLLDKESI SENPTLDLPC SIGRTEGTAH SSNTSDVDFT GASSAKETTS SSISRHYGLS DSRKRTRTGR SWPAAIPHLR RRRGRLPRRA LQTQNSEIVK DDEGKEDYQF DELNTEILNN LADQELQLNH LKNSITSYFG AAGRIACGEK YRVLARRVTL DGKVQYLVEW EGATAS
靶标信息
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hPCl2; Metal regulatory transcription factor 2; metal response element-binding transcription factor 2; Metal-response element DNA-binding protein M96; Metal-response element-binding transcription factor 2; polycomb-like 2; Polycomb-like protein 2; putative DNA binding protein; RP5-976O13.1; tudor domain containing 19A
基因别名: dJ976O13.2; M96; MTF2; PCL2; TDRD19A
UniProt ID: (Human) Q9Y483
Entrez Gene ID: (Human) 22823
negative regulation of transcription from RNA polymerase II promoter
segment specification
covalent chromatin modification
stem cell population maintenance
negative regulation of gene expression, epigenetic
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
negative regulation of histone H3-K27 methylation
positive regulation of histone H3-K27 methylation
