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The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DnaJ (Hsp40) homolog, subfamily C, member 1; DnaJ homolog subfamily C member 1; DnaJ protein homolog MTJ1; DnaJ-like protein; DnaJ-like protein 1
基因别名: 4733401K02Rik; AA960110; D230036H06Rik; DNAJC1; DNAJL1; ERdj1; ERj1p; HTJ1; MTJ1
UniProt ID: (Human) Q96KC8, (Mouse) Q61712
Entrez Gene ID: (Human) 64215, (Mouse) 13418