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MUC1 Antibody (PA5-95191) in IHC (P)
Immunohistochemistry analysis of MUC1 in paraffin-embedded mouse lung tissue. Samples were incubated with MUC1 polyclonal antibody (Product # PA5-95191).
产品信息
PA5-95191
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived mouse MUC1 recombinant protein (Position: S474-L630).
偶联物
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2806996
产品详细信息
Mouse MUC1 shares 87% amino acid (aa) sequence identity with human MUC1.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. MUC1 is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis, and sequential addition and processing of numerous O-linked glycans that are heavily sialylated. MUC1 is highly polymorphic and each allele encodes a product that contains a different number of repeats (between 30 and 90) leading to large differences in molecular weight of the protein. MUC1 is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells, and is expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. Overexpression, aberrant intracellular localization, and changes in glycosylation of the MUC1 protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of the MUC1 gene have been reported, but the full-length nature of only some has been determined. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD227; Episialin; J19; MUC-1; MUC1-alpha; mucin 1, transmembrane; Mucin-1; Mucin1
基因别名: CD227; EMA; Muc-1; Muc1
UniProt ID: (Mouse) Q02496
Entrez Gene ID: (Rat) 24571, (Mouse) 17829
response to hypoxia
in utero embryonic development
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
female pregnancy
negative regulation of transcription by competitive promoter binding
epithelial cell differentiation
positive regulation of transcription from RNA polymerase II promoter in response to stress
regulation of transcription from RNA polymerase II promoter in response to stress
cellular response to retinoic acid
positive regulation of histone H4 acetylation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
