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Immunogen sequence: RYSLTPEGLE LAQKLAESEG LSLLNVGIGP KEPPGEETAV PGAASAELAS EAGVQQQPLE LRPGEYRVLL CVDIGETRGG GHRPELLREL QRLHVTHTVR KLHVGDFVWV AQETNPRDPA NPGELVLDHI VERKRLDDLC SSIIDGRFRE QKFRLKRCGL ERRVYLVEEH GSVHNLSLPE STLLQAVTNT QVIDGFFVKR TADIKESAAY LALLTRGLQR LYQGHTLRSR PWGTPGNPES GAMTSPNPLC SLLTFSDFNA GAIKNKAQSV REVFARQLMQ VRGVSGEKAA ALVDRYSTPA SLLAAYDACA TPKEQETLLS TIKCGRLQRN LGPALSRTLS QLYCSYGPLT
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Crossover junction endonuclease MUS81; FLJ21012; FLJ44872 MUS81; MUS81 endonuclease homolog; SLX3 structure-specific endonuclease subunit homolog
基因别名: MUS81; SLX3
UniProt ID: (Human) Q96NY9
Entrez Gene ID: (Human) 80198