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产品信息
PA5-36985
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 414-459 of human MX2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553850
产品详细信息
This antibody detects endogenous protein at a molecular weight of 82 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
Members of the Dynamin family include GTPase, microtubule-associated proteins that are involved in cellular trafficking, including microtubule bundling and endocytosis. Mx1, also known as MxA, an interferon (IFN)-induced protein, acquires a high degree of resistance to influenza A virus and the rhabdo-virus vesicular stomatitis virus (VSV), which suggests that Mx1 plays an active role against influenza virus and the rhabdovirus VSV. Mx1 is a cytoplasmic protein that is 63% identical to the Mx2 protein, which lacks antiviral activity. Mx2 is also known as MxB and is localized at the cytoplasmic face of nuclear pores. Mx2 expression is not interferon-dependent and this protein is thought to regulate the efficiency and/or kinetics of nuclear import, a function which may have been usurped by its antiviral relatives.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Interferon-induced GTP-binding protein Mx2; interferon-induced GTP-binding protein Mx3; Interferon-regulated resistance GTP-binding protein MxB; MX dynamin-like GTPase 2; myxovirus (influenza virus) resistance 2; myxovirus (influenza virus) resistance 3; Myxovirus resistance protein 2; myxovirus resistance protein 3; p78-related protein; protein MxB; second interferon-induced protein p78
基因别名: AI528743; Mx-2; MX2; Mx3; MXB
UniProt ID: (Human) P20592, (Mouse) Q9WVP9
Entrez Gene ID: (Human) 4600, (Rat) 286918, (Mouse) 17858
defense response
response to virus
protein transport
response to interferon-alpha
regulation of nucleocytoplasmic transport
mRNA transport
defense response to virus
regulation of cell cycle
type I interferon signaling pathway
metabolic process
response to type I interferon
negative regulation of viral genome replication
innate immune response
immune system process
