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Proteintech

MXD1 Polyclonal Antibody

6 References

View all (6) MXD1 antibodies

Datasheet

Protocols

Tech Support

Catalog # 17888-1-AP

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150 µL

Datasheet

Protocols

Tech Support

Antibody Testing Data (2)

Application

FIGURE: 1 / 2

MXD1 Antibody (17888-1-AP) in WB

Mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 17888-1-AP (MXD1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Product Details

17888-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MXD1 Fusion Protein Ag12037 (1-221 aa encoded by BC098396)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAAVRMNI QMLLEAADYL ERREREAEHG YASMLPYNNK DRDALKRRNK SKKNNSSSRS THNEMEKNRR AHLRLCLEKL KGLVPLGPES SRHTTLSLLT KAKLHIKKLE DCDRKAVHQI DQLQREQRHL KRQLEKLGIE RIRMDSIGST VSSERSDSDR EEIDVDVEST DYLTGDLDWS SSSVSDSDER GSMQSLGSDE GYSSTSIKRI KLQDSHKACL GL (1-221 aa encoded by BC098396)

Target Information

MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression.

Science advances

Holmes AG,Parker JB,Sagar V,Truica MI,Soni PN,Han H,Schiltz GE,Abdulkadir SA,Chakravarti D

Fri Apr 29 00:00:00 UTC 2022

HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway.

Cell death & disease

Xiong F,Liu W,Wang X,Wu G,Wang Q,Guo T,Huang W,Wang B,Chen Y

Tue Sep 27 00:00:00 UTC 2022

The MicroRNA-382-5p/MXD1 Axis Relates to Breast Cancer Progression and Promotes Cell Malignant Phenotypes.

The Journal of surgical research

Zhang X,Zhao H,Zhang Y,Yang X,Zhang J,Yi M,Zhang C

Sat Feb 01 00:00:00 UTC 2020

MXD1 regulates the imatinib resistance of chronic myeloid leukemia cells by repressing BCR-ABL1 expression.

Leukemia research

Huan C,Jin L,Heng W,Na A,Yuming P,Xin D,Qiaoxia Z

Sat Dec 01 00:00:00 UTC 2018

MXD1 regulates the imatinib resistance of chronic myeloid leukemia cells by repressing BCR-ABL1 expression.

Leukemia research

Huan C,Jin L,Heng W,Na A,Yuming P,Xin D,Qiaoxia Z

Sat Dec 01 00:00:00 UTC 2018

Mxd1 mediates hypoxia-induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene.

Molecular carcinogenesis

Zheng D,Wu W,Dong N,Jiang X,Xu J,Zhan X,Zhang Z,Hu Z

Sun Oct 01 00:00:00 UTC 2017

Mxd1 mediates hypoxia-induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene.

Molecular carcinogenesis

Zheng D,Wu W,Dong N,Jiang X,Xu J,Zhan X,Zhang Z,Hu Z

Sun Oct 01 00:00:00 UTC 2017

miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression.

Oncology letters

Hu W,Jin P,Ding C,Liu W

Thu Sep 01 00:00:00 UTC 2016

miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression.

Oncology letters

Hu W,Jin P,Ding C,Liu W

Thu Sep 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: antagonizer of myc transcriptional activity; Max dimerization protein 1; Max dimerizer 1; MAX-binding protein; MGC104659; OTTHUMP00000202211; Protein MAD

Gene Aliases: AW122478; BHLHC58; MAD; Mad-1; MAD1; MXD1

UniProt ID: (Human) Q05195

Entrez Gene ID: (Human) 4084, (Rat) 362391, (Mouse) 17119

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity transcription corepressor activity protein binding protein dimerization activity DNA binding basic helix-loop-helix transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated multicellular organism development cell proliferation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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