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MYBBP1A Antibody (CL488-67996) in Flow
1X10^6 HepG2 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human MYBBP1A (CL488-67996, Clone:1H2D10) (red), or 0.4 µg Control Antibody. Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
产品信息
CL488-67996
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1H2D10
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein G
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20° C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: STALSSFLTK RNSPLTVPMF LSLFSRHPVL CQSLLPILVQ HITGPVRPRR QACLLLQKTL SMREVRSCFE DPEWKQLMGQ VLAKVTENLR VLGEAQTKAQ HQQALSSLEL LNVLFRTCKH EKLTLDLTVL LGVLQGQQQS LQQGAHSTGS SRLHDLYWQA MKTLGVQRPK LEKKDAKEIP SATQSPISKK RKKKGFLPET KKRKKRKSED GTPAEDGTPA ATGGSQPPSM GRKKRNRTKA KVPAQANGTP TTKSPAPGAP TRSPSTPAKS PKLQKKNQKP SQVNGAPGSP TEPAGQKQHQ KALPKKGVLG KSPLSALARK KARLSLVIRS PSLLQSGAKK KAQVRKAGKP
靶标信息
The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth and transactivating gene expression. c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, cellular levels of c-Myb decreasing as cells reach terminal differentiation. Myb-binding protein 1A (MYBBP1A) is a novel nuclear protein localized predominantly, but not exclusively, in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously, and associates with a number of different transcription factors. MYBBP1A associates with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression. MYBBP1A is a powerful negative regulator of PPAR gamma coactivator 1 alpha (PGC-1 alpha) by p38 MAPK and also acts as a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MYB binding protein 1a; MYB binding protein (P160) 1a; Myb-binding protein 1A; Myb-binding protein of 160 kDa; nuclear protein P160; p53-activated protein-2; PAR interacting protein; PAR-interacting protein; PIP
基因别名: AL024407; AU019902; DBP; MYBBP1A; P160; p160MBP; p67MBP; PAP2
UniProt ID: (Human) Q9BQG0, (Rat) O35821, (Mouse) Q7TPV4
Entrez Gene ID: (Human) 10514, (Rat) 60571, (Mouse) 18432
osteoblast differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
nucleocytoplasmic transport
respiratory electron transport chain
circadian regulation of gene expression
cellular response to glucose starvation
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of cell cycle arrest
DNA biosynthetic process
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of anoikis
rhythmic process
