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产品信息
PA5-69132
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide corresponding to a region of mouse MYH7
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2688385
产品详细信息
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
靶标信息
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cardiac muscle myosin heavy chain 7 beta; cardiac myosin heavy chain beta isoform; MYH-beta/slow; MyHC-beta; MyHC-slow; myopathy, distal 1; Myosin heavy chain 7; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, fetal; myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A
基因别名: B-MHC; beta-MHC; CMD1S; CMH1; MPD1; MYH7; Myhc-b; MyHC-I; MYHCB; SPMD; SPMM
UniProt ID: (Human) P12883, (Mouse) Q91Z83
Entrez Gene ID: (Human) 4625, (Mouse) 140781
regulation of the force of heart contraction
regulation of heart rate
skeletal muscle contraction
muscle contraction
striated muscle contraction
adult heart development
regulation of the force of skeletal muscle contraction
transition between fast and slow fiber
muscle filament sliding
regulation of slow-twitch skeletal muscle fiber contraction
ATP metabolic process
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
metabolic process
