Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 2
MYO5A Antibody (PA5-101689) in ICC/IF
Immunocytochemistry analysis of MYO5A in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with MYO5A polyclonal antibody (Product # PA5-101689) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-101689
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MYO5A(Accession Q9Y4I1), corresponding to amino acid residues L1783-P1833.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851123
产品详细信息
Antibody detects endogenous levels of total MYO5A.
靶标信息
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: dilute lethal-20J protein; Dilute myosin heavy chain, non-muscle; dilute-opisthotonus; flailer; myosin 5a; Myosin heavy chain 12; myosin V; myosin VA (heavy chain 12, myoxin); myosin, heavy polypeptide kinase; Myosin-12; myosin-Va; Myoxin; OTTMUSP00000017756; OTTMUSP00000019176; OTTMUSP00000046608; Unconventional myosin-Va
基因别名: 9630007J19Rik; AI413174; AI661011; D; d-120J; Dbv; Dilute; Dop; flail; flr; GS1; MVa; MYH12; MYO5; MYO5A; MyoVA; MYR12; Sev-1
UniProt ID: (Human) Q9Y4I1, (Mouse) Q99104, (Rat) Q9QYF3
Entrez Gene ID: (Human) 4644, (Mouse) 17918, (Rat) 25017
microfilament motor activity
actin binding
calcium ion binding
calmodulin binding
ATP binding
Rab GTPase binding
poly(A) RNA binding
SNARE binding
nucleotide binding
motor activity
protein binding
syntaxin-1 binding
ATP-dependent protein binding
protein heterodimerization activity
protein dimerization activity
calcium-dependent protein binding
actin binding motor protein
transport
exocytosis
post-Golgi vesicle-mediated transport
chemical synaptic transmission
visual perception
vesicle-mediated transport
actin filament-based movement
vesicle transport along actin filament
insulin secretion
melanocyte differentiation
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
locomotion involved in locomotory behavior
secretory granule localization
melanosome transport
cellular response to insulin stimulus
odontogenesis
myelination
long-chain fatty acid biosynthetic process
synapse organization
endoplasmic reticulum localization
protein localization to plasma membrane
regulation of Golgi organization
melanin metabolic process
metabolic process
protein transport
regulation of exocytosis
melanosome localization
anagen
pigmentation
developmental pigmentation
neuromuscular process controlling balance
