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产品信息
66214-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
5D1D12
抗原
MYOD1 Fusion Protein Ag13512 (1-320 aa encoded by BC064493)
偶联物
Unconjugated
形式
Liquid
浓度
1.47 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MELLSPPLR DVDLTAPDGS LCSFATTDDF YDDPCFDSPD LRFFEDLDPR LMHVGALLKP EEHSHFPAAV HPAPGAREDE HVRAPSGHHQ AGRCLLWACK ACKRKTTNAD RRKAATMRER RRLSKVNEAF ETLKRCTSSN PNQRLPKVEI LRNAIRYIEG LQALLRDQDA APPGAAAAFY APGPLPPGRG GEHYSGDSDA SSPRSNCSDG MMDYSGPPSG ARRRNCYEGA YYNEAPSEPR PGKSAAVSSL DCLSSIVERI STESPAAPAL LLADVPSESP PRRQEAAAPS EGESSGDPTQ SPDAAPQCPA GANPNPIYQV L (1-320 aa encoded by BC064493)
靶标信息
The Myogenic determination gene (MyoD) was first identified by the virtue of its ability to convert embryonic mouse fibroblast cells to muscle cells. It was subsequently shown that forced expression of MyoD (human homolog is myf 3) gene in a wide variety of normal and neoplastic cells could either convert the cells to muscle cells or activate a set of the otherwise transcriptionally inactive muscle-specific genes in these cells. The regulatory domain of the MyoD gene product lies within a 70 amino acid region and comprises a basic DNA binding motif and a helix-loop-helix (HLH) dimerization motif. Subsequent studies identified three other genes whose products shared sequence homology for the basic HLH domain of MyoD. These are; myf5, myogenin (human homolog is myf4) and myf6 (also known as MRF4 and herculin).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bHLHc1; Class C basic helix-loop-helix protein 1; eukaryotic myogenic factor MYF-3; Myf-3; Myoblast determination protein 1; Myogenic factor 3; myogenic regulatory factor
基因别名: AI503393; BHLHC1; MUF3; MYF-3; MYF3; MYOD; Myod-1; MYOD1; PUM
UniProt ID: (Human) P15172, (Pig) P49811, (Mouse) P10085, (Rat) Q02346
Entrez Gene ID: (Human) 4654, (Pig) 407604, (Mouse) 17927, (Rat) 337868
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
transcription factor binding
chromatin DNA binding
ubiquitin protein ligase binding
nuclear hormone receptor binding
protein heterodimerization activity
E-box binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein dimerization activity
promoter-specific chromatin binding
enzyme binding
sequence-specific DNA binding
basic helix-loop-helix transcription factor
regulation of alternative mRNA splicing, via spliceosome
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein phosphorylation
muscle organ development
myoblast fate determination
skeletal muscle tissue development
myoblast fusion
cellular response to starvation
myotube cell development
myotube differentiation involved in skeletal muscle regeneration
skeletal muscle cell differentiation
muscle cell fate commitment
positive regulation of skeletal muscle tissue regeneration
regulation of RNA splicing
skeletal muscle fiber adaptation
histone H3 acetylation
histone H4 acetylation
positive regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
skeletal muscle fiber development
positive regulation of skeletal muscle fiber development
positive regulation of muscle cell differentiation
cellular response to glucocorticoid stimulus
cellular response to estradiol stimulus
cellular response to oxygen levels
positive regulation of myoblast fusion
negative regulation of myoblast proliferation
transcription, DNA-templated
myoblast differentiation
striated muscle cell differentiation
positive regulation of snRNA transcription by RNA polymerase II
regulation of transcription, DNA-templated
multicellular organism development
myotube differentiation
cell differentiation
skeletal muscle tissue regeneration
positive regulation of transcription, DNA-templated
cardiac muscle cell differentiation
skeletal muscle atrophy
response to muscle stretch
