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Mast Cell Chymase Antibody (PA5-97599) in WB
Western Blot analysis of Mast Cell Chymase using a Mast Cell Chymase Polyclonal antibody (Product # PA5-97599) at a concentration of 3 µg/mL. Positive WB detected in: MCF-7 whole cell lysate, Mouse spleen tissue, Mouse lung tissue, Mouse kidney tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 28 kDa.
产品信息
PA5-97599
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Chymase protein (22-247AA)
偶联物
形式
Liquid
浓度
3 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2812214
靶标信息
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11. 2 in a cluster of genes encoding other proteases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-chymase; Chymase; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; chymase, heart; chymase, mast cell; mast cell; Mast cell chymase 1; Mast cell protease 5; Mast cell protease I; mMCP-5
基因别名: chymase; CMA1; CYH; CYM; Mcp-5; Mcp5; Mcpt5; MCT1; MMCP-5
UniProt ID: (Human) P23946, (Mouse) P21844
Entrez Gene ID: (Human) 1215, (Mouse) 17228
