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Melanophilin Antibody (PA5-100044) in IHC (P)
Immunohistochemistry analysis of Melanophilin in mouse heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Melanophilin polyclonal antibody (Product # PA5-100044) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100044
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MLPH(Accession Q9BV36), corresponding to amino acid residues K539-H589.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815574
产品详细信息
Antibody detects endogenous levels of total Melanophilin.
靶标信息
Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Exophilin-3; leaden; Leaden protein; Melanophilin; MGC2771; MGC59733; OTTMUSP00000025451; SlaC2-a; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a
基因别名: 2210418F23Rik; 5031433I09Rik; AW228792; D1Wsu84e; l(1)-3Rk; l1Rk3; Ln; MLPH; Slac-2a; SLAC2-A; SLAC2A
UniProt ID: (Human) Q9BV36, (Mouse) Q91V27
Entrez Gene ID: (Human) 79083, (Mouse) 171531, (Rat) 316620
