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This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Mel-1A-R; mel1a melatonin receptor; Mel1a receptor; Melatonin receptor type 1A
基因别名: MEL-1A-R; MelR; MR; MT1; MTNR1A
UniProt ID: (Human) P48039, (Mouse) Q61184
Entrez Gene ID: (Human) 4543, (Mouse) 17773, (Rat) 114211