Bioss

Metallothionein 3 Polyclonal Antibody

查看其他3个MT3抗体
说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

BS-4940R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:300-1:1,000
-

免疫组化（石蜡） (IHC (P))

1:200
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

流式细胞分析 (Flow)

1:20-1:100
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human Metallothionein 3, amino acids 1-68.
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Metallothionein (MT) is a sulfhydryl- and cysteine-rich protein found in micro-organisms, plants and all invertebrate and vertebrate animals. Metallothioneins are a group of ubiquitous low-molecular-weight proteins that have functional roles in cell growth, repair and differentiation. Metallothionein are implicated primarily in metal ion detoxification as they are essential for the protection of cells against the toxicity of cadmium, mercury and copper. Metallothioneins are known to be broadly expressed in heart, liver, kidney, breast and testis tissue. Metallothionein 3, also known as MT-3 or GIFB (growth inhibitory factor), is a 68 amino acid protein that belongs to the type 1 family and Metallothionein superfamily. While highly expressed in astrocytes of the normal human brain, Metallothionein 3 expression is reduced in the brains of patients with Alzheimer disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: GIF; GIFB; Growth inhibitory factor; metallothionein 3 (growth inhibitory factor (neurotrophic)); metallothionein III; Metallothionein-3; Metallothionein-III; MT-3; MT-III

查看更多 收起

基因别名: GIF; GIFB; GRIF; Mt-3; MT3; ZnMT3

查看更多 收起

UniProt ID: (Human) P25713, (Rat) P37361, (Mouse) P28184

查看更多 收起

Entrez Gene ID: (Human) 4504, (Rat) 117038, (Mouse) 17751

查看更多 收起

功能
copper ion binding protein binding drug binding zinc ion binding antioxidant activity protein kinase activator activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process cadmium ion binding metal ion binding
参与通路
protein import into nucleus, translocation response to hypoxia positive regulation of protein phosphorylation energy reserve metabolic process cholesterol catabolic process zinc II ion transport cellular metal ion homeostasis cellular zinc ion homeostasis response to oxidative stress brain development negative regulation of autophagy positive regulation of gene expression positive regulation of necrotic cell death positive regulation of cell death astrocyte development histone modification removal of superoxide radicals negative regulation of cell growth negative regulation of axon extension positive regulation of vascular endothelial growth factor receptor signaling pathway regulation of response to food activation of protein kinase B activity leptin-mediated signaling pathway cellular response to oxidative stress cellular response to drug positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress negative regulation of apoptotic process positive regulation of catalytic activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase B signaling negative regulation of neuron apoptotic process cellular lipid catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of neurogenesis negative regulation of dendrite morphogenesis protein stabilization negative regulation of oxidoreductase activity zinc ion homeostasis cadmium ion homeostasis regulation of protein glycosylation negative regulation of necrotic cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to cadmium ion cellular response to hypoxia cellular response to nitric oxide positive regulation of lysosomal membrane permeability negative regulation of neuron death negative regulation of cysteine-type endopeptidase activity negative regulation of hydrogen peroxide catabolic process positive regulation of oxygen metabolic process negative regulation of reactive oxygen species metabolic process apoptotic process cell proliferation response to metal ion
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持