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产品信息
MA5-15762
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
2E9C2
抗原
Recombinant protein corresponding to amino acids 176 to 280 of human MyD88.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153821
产品详细信息
A suggested positive control is EL4 cell lysate.
靶标信息
Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL-1R and is involved in the inflammatory response induced by IL-1, IL-18 and LPS. MyD88 recruits IRAK to IL-1 receptor complex in response to IL-1. This pathway further leads to activation of NF-kB. MyD88 has a wide tissue distribution.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: mutant myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); Myeloid differentiation primary response protein MyD88
基因别名: MYD88; MYD88D
UniProt ID: (Human) Q99836, (Mouse) P22366
Entrez Gene ID: (Human) 4615, (Mouse) 17874
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
apoptotic process
inflammatory response
signal transduction
cell surface receptor signaling pathway
positive regulation of type I interferon production
positive regulation of interleukin-17 production
positive regulation of interleukin-23 production
positive regulation of interleukin-6 production
toll-like receptor 9 signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
response to interleukin-1
3'-UTR-mediated mRNA stabilization
cellular response to mechanical stimulus
response to molecule of fungal origin
immune system process
immune response
transmembrane receptor protein serine/threonine kinase signaling pathway
JNK cascade
Toll signaling pathway
response to virus
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
lipopolysaccharide-mediated signaling pathway
response to peptidoglycan
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
regulation of cell proliferation
negative regulation of growth of symbiont in host
positive regulation of chemokine biosynthetic process
type I interferon biosynthetic process
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
establishment of endothelial intestinal barrier
