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Immunogen sequence: PTKIIFLNNTG GLRDSSHKVL SNVNLPADLD LVCNAEWVST KERQQMRLIV DVLSRLPHHS SAVITAASTL LTELFSNKGS GTLFKNAERM LRVRSLDKLD QGRLVDLV
Highest antigen sequence identity to the following orthologs - mouse 87%, rat 90%.
NAGS is a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Amino-acid acetyltransferase; MGC133025; N-acetylglutamate synthase, mitochondrial
基因别名: AGAS; ARGA; NAGS
UniProt ID: (Human) Q8N159
Entrez Gene ID: (Human) 162417