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产品信息
PA5-116672
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1370-1473 of human NLRP1 (NP_1274971)
偶联物
形式
Liquid
浓度
1.39 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901303
产品详细信息
Positive Samples: HeLa, SH-SY5Y
Immunogen sequence: PSPLDAPQLL HFVDQYREQL IARVTSVEVV LDKLHGQVLS QEQYERVLAE NTRPSQMRKL FSLSQSWDRK CKDGLYQALK ETHPHLIMEL WEKGSKKGLL PLSS
靶标信息
NALP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: caspase recruitment domain protein; caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; DKFZp586O1822; nacht; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT, LRR and PYD domains-containing protein 1a allele 1; NACHT/LRR/pyrin domain-containing protein 1; NLR family protein 1; NLR family, pyrin domain containing 1; NLR family, pyrin domain containing 1A; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; resistant anthrax lethal toxin
基因别名: CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; Gm14; Gm15; KIAA0926; NAC; NALP1; Nalp1a; NLRP1; Nlrp1a; PP1044; SLEV1; VAMAS1
UniProt ID: (Human) Q9C000, (Mouse) Q2LKU9, (Rat) D9I2F9
Entrez Gene ID: (Human) 22861, (Mouse) 195046, (Rat) 360557
response to muramyl dipeptide
defense response to bacterium
positive regulation of interleukin-1 beta secretion
programmed necrotic cell death
activation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of apoptotic process
neuron apoptotic process
apoptotic process
inflammatory response
innate immune response
regulation of inflammatory response
