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NBS1 Antibody (A301-284A) in WB
Detection of mouse NBS1 by western blot. Samples: Whole cell lysate (50 µg) from L1210 and CT26.WT cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-NBS1 antibody (Product # A301-284A) (lot A301-284A-2) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
产品信息
A301-284A
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 701 and 751 of mouse Nibrin.
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.^M
^M
Based on 100% sequence identity, this antibody is predicted to react with Rat
靶标信息
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT V1; AT V2; Cell cycle regulatory protein p95; FLJ10155; MGC87362; Nibrin; Nijmegen breakage syndrome protein 1 homolog; OTTHUMP00000204088; p95-NBS1
基因别名: Nbn; Nbs1
UniProt ID: (Mouse) Q9R207
Entrez Gene ID: (Mouse) 27354
DNA damage checkpoint
telomere maintenance
in utero embryonic development
blastocyst growth
DNA repair
double-strand break repair
cellular response to DNA damage stimulus
cell cycle
mitotic cell cycle checkpoint
mitotic G2 DNA damage checkpoint
cell proliferation
positive regulation of cell proliferation
positive regulation of protein autophosphorylation
DNA duplex unwinding
positive regulation of kinase activity
isotype switching
negative regulation of neuron differentiation
negative regulation of viral entry into host cell
regulation of fibroblast proliferation
neuromuscular process controlling balance
meiotic cell cycle
intrinsic apoptotic signaling pathway
