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产品信息
13382-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NCAPD2 Fusion Protein Ag4219 (1-351 aa encoded by BC028182)
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAPQMYEFH LPLSPEELLK SGGVNQYVVQ EVLSIKHLPP QLRAFQAAFR AQGPLAMLQH FDTIYSILHH FRSIDPGLKE DTLEFLIKVV SRHSQELPAI LDDTTLSGSD RNAHLNALKM NCYALIRLLE SFETMASQTN LVDLDLGGKG KKARTKAAHG FDWEEERQPI LQLLTQLLQL DIRHLWNHSI IEEEFVSLVT GCCYRLLENP TINHQKNRPT REAITHLLGV ALTRYNHMLS ATVKIIQMLQ HFEHLAPVLV AAVSLWATDY GMKSIVGEIV REIGQKCPQE LSRDPSGTKG FAAFLTELAE RVPAILMSSM CILLDHLDGE NYMMRNAVLA AMAEMVLQVL SG (1-351 aa encoded by BC028182)
靶标信息
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: chromosome condensation related SMC associated protein 1; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; Condensin complex subunit 1; hCAP-D2; mCAP-D2; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2; XCAP-D2 homolog
基因别名: 2810406C15Rik; 2810465G24Rik; CAP-D2; CAPD2; CNAP1; hCAP-D2; KIAA0159; mKIAA0159; NCAPD2; RGD1562596
UniProt ID: (Human) Q15021, (Mouse) Q8K2Z4
Entrez Gene ID: (Human) 9918, (Rat) 362438, (Mouse) 68298
