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NCOA6 Antibody (PA5-100633) in IHC (P)
Immunohistochemistry analysis of NCOA6 in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with NCOA6 polyclonal antibody (Product # PA5-100633) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100633
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NCOA6(Accession Q14686), corresponding to amino acid residues S884-D934.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850139
产品详细信息
Antibody detects endogenous levels of total NCOA6.
靶标信息
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activating signal cointegrator 2; activating signal cointegrator-2; Amplified in breast cancer protein 3; amplified in breast cancer-3 protein; ASC-2; Cancer-amplified transcriptional coactivator ASC-2; NRC RAP250; Nuclear receptor coactivator 6; Nuclear receptor coactivator RAP250; nuclear receptor-activating protein 250; Nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein; peroxisome proliferator-activated receptor interacting protein,PRIP; Peroxisome proliferator-activated receptor-interacting protein; PPAR interacting protein PRIP; PPAR-interacting protein; thyroid hormone receptor binding protein; Thyroid hormone receptor-binding protein
基因别名: AIB3; ASC-2; ASC2; KIAA0181; mKIAA0181; NCOA6; Ncoa7; NRC; PRIP; RAP250; TRBP
UniProt ID: (Human) Q14686
Entrez Gene ID: (Human) 23054, (Mouse) 56406, (Rat) 116464
chromatin binding
transcription coactivator activity
protein binding
ligand-dependent nuclear receptor binding
enzyme binding
protein domain specific binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
glucocorticoid receptor binding
protein homodimerization activity
peroxisome proliferator activated receptor binding
retinoid X receptor binding
thyroid hormone receptor binding
nuclear hormone receptor binding
retinoic acid receptor binding
chromatin/chromatin-binding, or -regulatory protein
ovarian follicle development
DNA replication
DNA repair
DNA recombination
DNA-templated transcription, initiation
transcription initiation from RNA polymerase II promoter
cellular response to DNA damage stimulus
brain development
heart development
response to hormone
myeloid cell differentiation
intracellular estrogen receptor signaling pathway
positive regulation of insulin secretion involved in cellular response to glucose stimulus
glucocorticoid receptor signaling pathway
cellular lipid metabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
labyrinthine layer blood vessel development
positive regulation of peptide secretion
regulation of nucleic acid-templated transcription
