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NCoR2 Antibody (PA5-141074) in WB
Western blot analysis of NCOR2/SMRT in different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. Samples were incubated in NCOR2/SMRT Polyclonal antibody (Product # PA5-141074) using a dilution of 1:1,000 in 5% BSA at room temperature for 2 hours followed by Goat Anti-Rabbit IgG - HRP secondary antibody at a dilution of 1:200,000 for 1 hour at room temperature. Positive control: Lane 1: Mouse brain tissue lysate; Lane 2: Rat brain tissue lysate.
产品信息
PA5-141074
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein within N-terminal human NCOR2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2932526
靶标信息
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTG repeat protein 26; N-CoR2; nuclear receptor corepressor; Nuclear receptor corepressor 2; silencing mediator for retinoid and thyroid hormone receptors; Silencing mediator of retinoic acid and thyroid hormone receptor; silencing mediator of retinoid acid and thyroid hormone receptor; SMAP270; SMRT; T3 receptor-associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor; TRAC
基因别名: CTG26; N-CoR; N-CoR2; NCOR2; SMAP270; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC; TRAC-1; TRAC1
UniProt ID: (Human) Q9Y618, (Mouse) Q9WU42
Entrez Gene ID: (Human) 9612, (Mouse) 20602, (Rat) 360801
DNA binding
transcription corepressor activity
Notch binding
protein binding
transcription factor binding
ligand-dependent nuclear receptor binding
histone deacetylase binding
protein N-terminus binding
RNA polymerase II regulatory region DNA binding
chromatin binding
protein complex binding
glucocorticoid receptor binding
retinoic acid receptor binding
sequence-specific DNA binding
retinoid X receptor binding
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
cellular lipid metabolic process
regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
negative regulation of production of miRNAs involved in gene silencing by miRNA
in utero embryonic development
heart morphogenesis
regulation of transcription, DNA-templated
telencephalon development
cell proliferation in forebrain
forebrain development
glucose homeostasis
negative regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
white fat cell differentiation
Type I pneumocyte differentiation
positive regulation of protein deacetylation
lactation
response to organonitrogen compound
response to estradiol
estrous cycle
