Bethyl Laboratories

NEDD4L Polyclonal Antibody

查看其他21个NEDD4L抗体

产品信息

A302-512A-T

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

免疫沉淀 (IP)

Assay-dependent

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Between 225 and 275

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Antigen affinity chromatography

保存液

TBS, pH 7.0 to 8.0, with 0.1% BSA

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Wet ice

产品详细信息

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Orangutan

靶标信息

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; Nedd4-2; NEDD4.2; neural precursor cell expressed, developmentally down-regulated gene 4b; ubiquitin-protein ligase Rsp5

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基因别名: 1300012C07Rik; hNEDD4-2; KIAA0439; NEDD4-2; NEDD4.2; Nedd4b; NEDD4L; NEDL3; RSP5

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UniProt ID: (Human) Q96PU5

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Entrez Gene ID: (Human) 23327, (Mouse) 83814

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ubiquitin-protein transferase activity protein binding potassium channel regulator activity ligase activity sodium channel regulator activity potassium channel inhibitor activity sodium channel inhibitor activity ion channel binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity ubiquitin protein ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity ubiquitin-protein ligase

参与通路

negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination regulation of membrane depolarization protein monoubiquitination sodium ion transport cellular sodium ion homeostasis excretion response to metal ion protein ubiquitination viral life cycle water homeostasis ion transmembrane transport regulation of ion transmembrane transport regulation of protein catabolic process regulation of membrane potential protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process positive regulation of endocytosis regulation of membrane repolarization protein K48-linked ubiquitination ventricular cardiac muscle cell action potential regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transport negative regulation of sodium ion transmembrane transport positive regulation of dendrite extension negative regulation of protein localization to cell surface negative regulation of sodium ion transmembrane transporter activity positive regulation of caveolin-mediated endocytosis negative regulation of systemic arterial blood pressure response to salt stress positive regulation of sodium ion transport negative regulation of sodium ion transport ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway regulation of bicellular tight junction assembly positive regulation of cation channel activity