Invitrogen

NEDD4L Polyclonal Antibody

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抗体检测数据 (2)

NEDD4L Antibody in Western Blot (WB)

NEDD4L Antibody in Western Blot (WB)

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NEDD4L Antibody (PA5-42310) in WB

Western blot analysis of human cystic fibrosis epithelial cells using an anti-NEDD4L polyclonal antibody (Product # PA5-42310).

NEDD4L Antibody in Western Blot (WB)

NEDD4L Antibody in Western Blot (WB)

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NEDD4L Antibody in Western Blot (WB) — Western blot analysis of human cystic fibrosis epithelial cells using an anti-NEDD4L polyclonal antibody (Product # PA5-42310).

NEDD4L Antibody in Western Blot (WB) — Western blot analysis of human PANC1 cell lysate using an anti-NEDD4L polyclonal antibody (Product # PA5-42310).

产品信息

PA5-42310

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the middle region of human NEDD4L

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2605949

产品详细信息

Peptide sequence: TVTLSAPLEG AKDSPVRRAV KDTLSNPQSP QPSPYNSPKP QHKVTQSFLP

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

靶标信息

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: E3 ubiquitin-protein ligase NEDD4-like; FLJ33870; HECT-type E3 ubiquitin transferase NED4L; Nedd4-2; NEDD4.2; ubiquitin-protein ligase Rsp5

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基因别名: hNEDD4-2; KIAA0439; NEDD4-2; NEDD4.2; NEDD4L; NEDL3; RSP5

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UniProt ID: (Human) Q96PU5

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Entrez Gene ID: (Human) 23327

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ubiquitin-protein transferase activity protein binding potassium channel regulator activity ligase activity sodium channel regulator activity potassium channel inhibitor activity sodium channel inhibitor activity ion channel binding ubiquitin-protein ligase

参与通路

negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination regulation of membrane depolarization protein monoubiquitination sodium ion transport cellular sodium ion homeostasis excretion response to metal ion protein ubiquitination viral life cycle water homeostasis ion transmembrane transport regulation of ion transmembrane transport regulation of protein catabolic process regulation of membrane potential protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process positive regulation of endocytosis regulation of membrane repolarization protein K48-linked ubiquitination ventricular cardiac muscle cell action potential regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity negative regulation of potassium ion transmembrane transport negative regulation of sodium ion transmembrane transport positive regulation of dendrite extension negative regulation of protein localization to cell surface negative regulation of sodium ion transmembrane transporter activity positive regulation of caveolin-mediated endocytosis