Proteintech

NEIL1 Polyclonal Antibody

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NEIL1 Antibody (12145-1-AP) in WB

MCF-7 cells were subjected to SDS PAGE followed by western blot with 12145-1-AP (NEIL1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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产品信息

12145-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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免疫组化 (IHC)

Assay-dependent

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

NEIL1 Fusion Protein Ag2793 (1-390 aa encoded by BC010876)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.13 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MPEGPELHL ASQFVNEACR ALVFGGCVEK SSVSRNPEVP FESSAYRISA SARGKELRLI LSPLPGAQPQ QEPLALVFRF GMSGSFQLVP REELPRHAHL RFYTAPPGPR LALCFVDIRR FGRWDLGGKW QPGRGPCVLQ EYQQFRENVL RNLADKAFDR PICEALLDQR FFNGIGNYLR AEILYRLKIP PFEKARSVLE ALQQHRPSPE LTLSQKIRTK LQNPDLLELC HSVPKEVVQL GGRGYGSESG EEDFAAFRAW LRCYGMPGMS SLQDRHGRTI WFQGDPGPLA PKGRKSRKKK SKATQLSPED RVEDALPPSK APSRTRRAKR DLPKRTATQR PEGTSLQQDP EAPTVPKKGR RKGRQAASGH CRPRKVKADI PSLEPEGTSA S (1-390 aa encoded by BC010876)

靶标信息

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

DNA-Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol.

Journal of the American Chemical Society

Tang F,Yuan J,Yuan BF,Wang Y

Wed Jan 12 00:00:00 EST 2022

Breakage of cytoplasmic chromosomes by pathological DNA base excision repair.

Nature

Tang S,Stokasimov E,Cui Y,Pellman D

Wed Jun 01 00:00:00 EDT 2022

Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A.

Frontiers in cell and developmental biology

Sharma N,Thompson MK,Arrington JF,Terry DM,Chakravarthy S,Prevelige PE,Prakash A

Tue Jan 31 00:00:00 EST 2023

Mono- and biallelic germline variants of DNA glycosylase genes in colon adenomatous polyposis families from two continents.

Frontiers in oncology

Olkinuora AP,Mayordomo AC,Kauppinen AK,Cerliani MB,Coraglio M,Collia ÁK,Gutiérrez A,Alvarez K,Cassana A,Lopéz-Köstner F,Jauk F,García-Rivello H,Ristimäki A,Koskenvuo L,Lepistö A,Nieminen TT,Vaccaro CA,Pavicic WH,Peltomäki P

Fri Nov 18 00:00:00 EST 2022

Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker.

Scientific reports

Ye F,Liu J,Wang H,Chen X,Cheng Q,Chen H

Fri Mar 20 00:00:00 EDT 2020

Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells.

BioMed research international

Xue W,Liu Y,Xin N,Miao J,Du J,Wang Y,Shi H,Wei Y,Zhang H,Chen Y,Gao Y,Li D,Feng Y,Yan J,Zhang J,Hou N,Huang C,Han J

Fri Apr 16 00:00:00 EDT 2021

Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.

DNA repair

Quiñones JL,Thapar U,Wilson SH,Ramsden DA,Demple B

Sun Mar 01 00:00:00 EST 2020

Validating the concept of mutational signatures with isogenic cell models.

Nature communications

Zou X,Owusu M,Harris R,Jackson SP,Loizou JI,Nik-Zainal S

Tue May 01 00:00:00 EDT 2018

Validating the concept of mutational signatures with isogenic cell models.

Nature communications

Zou X,Owusu M,Harris R,Jackson SP,Loizou JI,Nik-Zainal S

Tue May 01 00:00:00 EDT 2018

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity.

Toxicology and applied pharmacology

Ma H,Wang J,Abdel-Rahman SZ,Hazra TK,Boor PJ,Khan MF

Tue Feb 15 00:00:00 EST 2011

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity.

Toxicology and applied pharmacology

Ma H,Wang J,Abdel-Rahman SZ,Hazra TK,Boor PJ,Khan MF

Tue Feb 15 00:00:00 EST 2011

生物信息学

蛋白别名: DNA endonuclease eight-like glycosylase 1; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease 8-like 1; endonuclease VIII; Endonuclease VIII-like 1; FLJ22402; FPG1; NEH1; nei endonuclease VIII-like 1; Nei homolog 1; nei-like DNA glycosylase 1; Nei-like protein 1

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基因别名: 2810450N13Rik; FPG1; hFPG1; NEI1; NEIL1

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UniProt ID: (Human) Q96FI4, (Mouse) Q8K4Q6

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Entrez Gene ID: (Human) 79661, (Rat) 367090, (Mouse) 72774

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