Proteintech

NF-H Monoclonal Antibody (1A3C7)

NF-H Antibody in Immunocytochemistry (ICC/IF)

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NF-H Antibody (60331-1-IG) in ICC/IF

Immunofluorescent analysis of SH-SY5Y cells using 60331-1-IG (NF200 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

NF-H Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

60331-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:8,000

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:20-1:200

查看7篇已发表文章 7篇已发表文章

流式细胞分析 (Flow)

Assay-dependent

产品规格

种属反应

Human, Mouse, Pig, Rat

已发表种属

Not Applicable

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

1A3C7

抗原

NF200 Fusion Protein Ag13517 (1-214 aa encoded by BC014185)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody recognize NEFH only.

Immunogen sequence: MMSFGGADA LLGAPFAPLH GGGSLHYALA RKGGAGGTRS AAGSSSGFHS WTRTSVSSVS ASPSRFRGAG AASSTDSLDT LSNGPEGCMV AVATSRSEKE QLQALNDRFA GYIDKVRQLE AHNRSLEGEA AALRQQQAGR SAMGELYERE VREMRGAVLR LGAARGQLRL EQEHLLEDIA HVRQRLDDEA RQREEAEAAA RALARFAQEA EAARV (1-214 aa encoded by BC014185)

靶标信息

Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-H has an important role in mature axons and is involved in amyotrophic lateral sclerosis (ALS).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 200 kDa neurofilament protein; NEF3; neurofilament; neurofilament 200kDa; Neurofilament heavy polypeptide; Neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa; NF 200 kD; NF-H; NHC

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基因别名: CMT2CC; KIAA0845; mKIAA0845; NEFH; NF-H; NF200; NFH

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UniProt ID: (Human) P12036, (Mouse) P19246

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Entrez Gene ID: (Human) 4744, (Pig) 100156492, (Rat) 24587, (Mouse) 380684

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功能

structural molecule activity structural constituent of cytoskeleton microtubule binding toxic substance binding kinesin binding protein kinase binding protein binding, bridging dynein binding protein heterodimerization activity nutrient reservoir activity

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