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产品信息
R1309-9
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within human NFkB p105 aa 320-366.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 0.2% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
靶标信息
NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.
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生物信息学
蛋白别名: DKFZp686C01211; DNA-binding factor KBF1; EBP-1; MGC54151; NF kappaB1; NF KB; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappaB p50; NF-kappabeta; nuclear factor; nuclear factor kappa b; nuclear factor kappa-B DNA binding subunit; nuclear factor kappaB p50; Nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; nuclear factor-kappaB p50; p50 subunit of NF kappaB; p50 subunit of NF-kappaB
基因别名: CVID12; EBP-1; KBF1; NF-kappa-B; NF-kappaB; NF-kappaB1; NF-KB1; NFkappaB; NFKB-p105; NFKB-p50; NFKB1; p105; p50; p50/p105
UniProt ID: (Human) P19838, (Mouse) P25799
Entrez Gene ID: (Human) 4790, (Mouse) 18033
regulatory region DNA binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
heat shock protein binding
identical protein binding
protein homodimerization activity
actinin binding
transcription regulatory region DNA binding
protein heterodimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
double-stranded DNA binding
sequence-specific DNA binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
stimulatory C-type lectin receptor signaling pathway
transcription from RNA polymerase II promoter
apoptotic process
inflammatory response
response to oxidative stress
I-kappaB kinase/NF-kappaB signaling
positive regulation of macrophage derived foam cell differentiation
positive regulation of lipid storage
negative regulation of calcidiol 1-monooxygenase activity
negative regulation of vitamin D biosynthetic process
membrane protein intracellular domain proteolysis
negative regulation of cellular protein metabolic process
negative regulation of cholesterol transport
positive regulation of type I interferon production
response to muscle stretch
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
negative regulation of apoptotic process
negative regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to copper ion
negative regulation of inflammatory response
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to nicotine
cellular response to carbohydrate stimulus
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to dsRNA
cellular response to peptide hormone stimulus
positive regulation of canonical Wnt signaling pathway
positive regulation of hyaluronan biosynthetic process
cellular response to diterpene
cellular response to glucoside
cellular response to brain-derived neurotrophic factor stimulus
positive regulation of miRNA metabolic process
negative regulation of cytokine production
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
signal transduction
response to cytokine
negative regulation of transcription, DNA-templated
lymph node development
