Search Thermo Fisher Scientific
Immunogen sequence: VFHPDSSEASS RKGVLDGYGA RRNEQRRYPQ KRPPWEVEGA RPRPGRNPPK QEGHRHTNAG HRNNMGPIPK DDLNERPAKS TCDSENLAVI NKSSR
Highest antigen sequence identity to the following orthologs - mouse 73%, rat 73%.
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZp779G2416; MGC20369; Nuclear transcription factor, X box-binding protein 1; Transcriptional repressor NF-X1; X-box binding 1
基因别名: NFX1; NFX2; TEG-42; Tex42
UniProt ID: (Human) Q12986
Entrez Gene ID: (Human) 4799