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Predicted Reactivity: Rat (91%), Rhesus Monkey (99%), Bovine (93%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: alymphoplasia; HsNIK; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; protein kinase; Serine/threonine-protein kinase NIK
基因别名: aly; FTDCR1B; HS; HSNIK; MAP3K14; NIK
UniProt ID: (Human) Q99558, (Mouse) Q9WUL6
Entrez Gene ID: (Human) 9020, (Mouse) 53859