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产品信息
MA5-16274
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Mouse
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
25N10E9
抗原
Recombinant mNLRP3 NOD domain protein (AA 216-385).
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2537791
靶标信息
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cold autoinflammatory syndrome 1 homolog; Cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; FLJ95925; mast cell maturation inducible protein 1; Mast cell maturation-associated-inducible protein 1; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; PYRIN-containing APAF1-like protein 1
基因别名: AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1; MWS; NALP3; Nlrp3; Pypaf1
UniProt ID: (Mouse) Q8R4B8
Entrez Gene ID: (Mouse) 216799
negative regulation of acute inflammatory response
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
negative regulation of NF-kappaB transcription factor activity
interleukin-1 beta production
interleukin-18 production
negative regulation of NF-kappaB import into nucleus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
NLRP3 inflammasome complex assembly
interleukin-1 secretion
negative regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
negative regulation of inflammatory response
positive regulation of NF-kappaB transcription factor activity
defense response to virus
cellular response to lipopolysaccharide
