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产品信息
PA5-61758
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644457
产品详细信息
Immunogen sequence: TLSHCKLPDA VCRDLSEALR AAPALTELGL LHNRLSEAGL RMLSEGLAWP QCRVQTVRVQ LPDPQRGLQY LVGMLRQSPA LTTLDLSGCQ LPAPMVTYLC AVL
Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 71%.
靶标信息
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NLR family, pyrin domain containing 6; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PYRIN-containing APAF1-like protein 5
基因别名: AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; NLRP6; PAN3; PYPAF5
UniProt ID: (Human) P59044
Entrez Gene ID: (Human) 171389
negative regulation of inflammatory response to antigenic stimulus
inflammatory response
G-protein coupled receptor signaling pathway
response to bacterium
regulation of autophagy
negative regulation of toll-like receptor signaling pathway
wound healing
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of inflammatory response
regulation of mucus secretion
negative regulation of ERK1 and ERK2 cascade
