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NMDAR3A Antibody (OSN00101W-100UL) in IHC (P)
IHC on paraffin sections of rat spinal cord tissue using Rabbit antibody to NMDAR3A (990-1040): OSN00101W. HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1:1000, incubated 30 min at RT (using Autostainer). Sections were counters... View More
产品信息
OSN00101W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 990-1040 of rat NMDAR3A conjugated to blue carrier protein was used as the antigen
偶联物
Unconjugated
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide shares 95% identity with mouse sequence.
Specificity of this antibody: NMDAR3A.
靶标信息
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Grin3a is mediated by glycine and may play a role in the development of dendritic spines. Further, Grin3a may play a role in PPP2CB-NMDAR mediated signaling mechanism. Grin3a belongs to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in Grin3a suggest that the protein may be involved in the development of synaptic elements by modulating NMDA receptor activity. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GluN3A; glutamate receptor; Glutamate receptor chi-1; Glutamate receptor ionotropic, NMDA 3A; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subtype 3A; NMDAR-L; NMDAR-L1; NMDAR3A
基因别名: chi-1; GluN3A; Grin3a; NR3
UniProt ID: (Rat) Q9R1M7
Entrez Gene ID: (Rat) 191573
