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A suggested positive control is human kidney tissue lysate.
PA5-20788 can be used with blocking peptide PEP-0902.
Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: [Wnt protein] O-palmitoleoyl-L-serine hydrolase; hNOTUM; notum pectinacetylesterase homolog; Palmitoleoyl-protein carboxylesterase NOTUM; protein notum homolog
基因别名: 5730593N15Rik; hNOTUM; NOTUM; OK/SW-CL.30; RGD1307119
UniProt ID: (Human) Q6P988, (Mouse) A2ABZ5
Entrez Gene ID: (Human) 147111, (Rat) 303743, (Mouse) 77583