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Application
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NOX4 Antibody (PA5-86798) in WB
Western blot analysis of NOX4 in Lane 1: HEK293T whole cell lysate (40 µg), Lane 2: MCF-7 whole cell lysate (40 µg), Lane 3: HepG2 whole cell lysate (40 µg), Lane 4: PC12 whole cell lysate (40 µg), Lane 5: AML-12 whole cell lysate (40 µg). Sample was incubated with NOX4 polyclonal antibody (Product # PA5-86798) using a 1:500 dilution.
产品信息
PA5-86798
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to residues in Human NOX4.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2803558
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; KOX1; NADPH oxidase 4; NOX 4; NOX-4; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4
基因别名: AI648021; KOX; KOX-1; NOX4; RENOX
UniProt ID: (Human) Q9NPH5, (Rat) Q924V1, (Mouse) Q9JHI8
Entrez Gene ID: (Human) 50507, (Rat) 85431, (Mouse) 50490
nucleotide binding
protein binding
electron carrier activity
NAD(P)H oxidase activity
superoxide-generating NADPH oxidase activity
oxygen sensor activity
heme binding
flavin adenine dinucleotide binding
modified amino acid binding
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
oxidoreductase activity
oxidase
response to reactive oxygen species
cell morphogenesis
response to hypoxia
superoxide metabolic process
inflammatory response
cell aging
negative regulation of cell proliferation
gene expression
positive regulation of smooth muscle cell migration
superoxide anion generation
positive regulation of apoptotic process
positive regulation of MAP kinase activity
bone resorption
homocysteine metabolic process
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
oxidation-reduction process
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
cellular response to glucose stimulus
cellular response to gamma radiation
cellular response to transforming growth factor beta stimulus
reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
aging
