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Invitrogen

NOX4 Recombinant Rabbit Monoclonal Antibody (SY0214)

Name: NOX4 Recombinant Rabbit Monoclonal Antibody (SY0214)
Brand: Invitrogen
SKU: MA532090
Price: 4917.0 CNY

9个已发表图片

10 篇参考文献

查看其他15个NOX4抗体

说明书

实验方案

技术支持

货号 MA5-32090

飞享价 CNY 2,999.00 4,917.00

活动截止日期 31-Mar-2025

100 µL

下单后预计有货时间 08-Apr-2025

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批量或定制请求

说明书

实验方案

技术支持

抗体检测数据 (8)
已发表图片 (9)

Application

NOX4 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 17

NOX4 Antibody (MA5-32090) in ICC/IF

Immunocytochemical analysis of NOX4 in A549 cells using a NOX4 Monoclonal antibody (Product # MA5-32090) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

NOX4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

NOX4 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

产品信息

MA5-32090

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000

查看7篇已发表文章 7篇已发表文章

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100

功能检测 (Functional)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

SY0214

抗原

Recombinant protein within Human NOX4 aa 460-578

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2809383

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Dexamethasone Induced Osteocyte Apoptosis in Steroid-Induced Femoral Head Osteonecrosis through ROS-Mediated Oxidative Stress.

Orthopaedic surgery

Zhang X,Yang Z,Xu Q,Xu C,Shi W,Pang R,Zhang K,Liang X,Li H,Li Z,Zhang H

Published figure using NOX4 recombinant monoclonal antibody (Product # MA5-32090) in Immunohistochemistry

Fri Mar 01 00:00:00 UTC 2024

Dexamethasone Induced Osteocyte Apoptosis in Steroid-Induced Femoral Head Osteonecrosis through ROS-Mediated Oxidative Stress.

Orthopaedic surgery

Zhang X,Yang Z,Xu Q,Xu C,Shi W,Pang R,Zhang K,Liang X,Li H,Li Z,Zhang H

Published figure using NOX4 recombinant monoclonal antibody (Product # MA5-32090) in Immunohistochemistry

Fri Mar 01 00:00:00 UTC 2024

NOX4 aggravates doxorubicin-induced cardiomyocyte pyroptosis by increasing reactive oxygen species content and activating the NLRP3 inflammasome.

Cardiovascular diagnosis and therapy

Zeng H,Zou P,Chen Y,Zhang P,Shao L

Published figure using NOX4 recombinant monoclonal antibody (Product # MA5-32090) in Western Blot

Thu Feb 15 00:00:00 UTC 2024

Simulated Microgravity Exposure Induces Antioxidant Barrier Deregulation and Mitochondria Enlargement in TCam-2 Cell Spheroids.

Cells

Berardini M,Gesualdi L,Morabito C,Ferranti F,Reale A,Zampieri M,Karpach K,Tinari A,Bertuccini L,Guarnieri S,Catizone A,Mariggiò MA,Ricci G

Published figure using NOX4 recombinant monoclonal antibody (Product # MA5-32090) in Western Blot

Sat Aug 19 00:00:00 UTC 2023

Simulated Microgravity Exposure Induces Antioxidant Barrier Deregulation and Mitochondria Enlargement in TCam-2 Cell Spheroids.

Cells

Berardini M,Gesualdi L,Morabito C,Ferranti F,Reale A,Zampieri M,Karpach K,Tinari A,Bertuccini L,Guarnieri S,Catizone A,Mariggiò MA,Ricci G

Published figure using NOX4 recombinant monoclonal antibody (Product # MA5-32090) in Western Blot

Sat Aug 19 00:00:00 UTC 2023

Role of the OTUB1/IRF7/NOX4 axis in oxidative stress injury and inflammatory responses in mice with Parkinson's disease.

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Xing X,Xu F,Wang Y,Liu H

MA5-32090 was used in Western Blotting to conclude that OTUB1-mediated deubiquitination stabilized IRF7 and upregulated NOX4 expression, thereby promoting oxidative stress injury (OSI) and inflammatory responses in Parkinson's disease (PD) mice.

Sun Jan 01 00:00:00 UTC 2023

Oxidative stress and inflammation distinctly drive molecular mechanisms of diastolic dysfunction and remodeling in female and male heart failure with preserved ejection fraction rats.

Frontiers in cardiovascular medicine

Zhazykbayeva S,Hassoun R,Herwig M,Budde H,Kovács Á,Mannherz HG,El-Battrawy I,Tóth A,Schmidt WE,Mügge A,Hamdani N

MA5-32090 was used in Western Blotting to suggest that oxidative stress and inflammation distinctly drive diastolic dysfunction and remodeling in female and male rats with HFpEF and that the sex-dependent mechanisms contribute to HF pathology.

Sat Jul 01 00:00:00 UTC 2023

Repetitive Transcranial Magnetic Stimulation Reduces Neuronal Loss and Neuroinflammation in Parkinson?s Disease Through the miR-195a-5p/CREB Axis.

Turkish neurosurgery

Sun L,Wang F,Han J,Bai L,DU J

MA5-32090 was used in Western Blotting to find that miR-195a-5p suppression enhanced cognitive and motor functions in PD mice.

Tue Apr 04 00:00:00 UTC 2023

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells.

iScience

Widjaja AA,Viswanathan S,Wei Ting JG,Tan J,Shekeran SG,Carling D,Lim WW,Cook SA

MA5-32090 was used in Functional Assay to identify the IL11/mTOR axis as a signaling commonality in stromal, epithelial, and cancer cells and reveal a shared IL11-driven mesenchymal program across cell types.

Fri Aug 19 00:00:00 UTC 2022

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.

Nature communications

Dong J,Viswanathan S,Adami E,Singh BK,Chothani SP,Ng B,Lim WW,Zhou J,Tripathi M,Ko NSJ,Shekeran SG,Tan J,Lim SY,Wang M,Lio PM,Yen PM,Schafer S,Cook SA,Widjaja AA

Published figure using NOX4 recombinant monoclonal antibody (Product # MA5-32090) in Western Blot

Mon Jan 04 00:00:00 UTC 2021

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.

Nature communications

Dong J,Viswanathan S,Adami E,Singh BK,Chothani SP,Ng B,Lim WW,Zhou J,Tripathi M,Ko NSJ,Shekeran SG,Tan J,Lim SY,Wang M,Lio PM,Yen PM,Schafer S,Cook SA,Widjaja AA

Published figure using NOX4 recombinant monoclonal antibody (Product # MA5-32090) in Western Blot

Mon Jan 04 00:00:00 UTC 2021

NOX1 Inhibition Attenuates Kidney Ischemia-Reperfusion Injury via Inhibition of ROS-Mediated ERK Signaling.

International journal of molecular sciences

Jung HY,Oh SH,Ahn JS,Oh EJ,Kim YJ,Kim CD,Park SH,Kim YL,Cho JH

Published figure using NOX4 recombinant monoclonal antibody (Product # MA5-32090) in Immunohistochemistry

Mon Sep 21 00:00:00 UTC 2020

NOX1 Inhibition Attenuates Kidney Ischemia-Reperfusion Injury via Inhibition of ROS-Mediated ERK Signaling.

International journal of molecular sciences

Jung HY,Oh SH,Ahn JS,Oh EJ,Kim YJ,Kim CD,Park SH,Kim YL,Cho JH

Published figure using NOX4 recombinant monoclonal antibody (Product # MA5-32090) in Immunohistochemistry

Mon Sep 21 00:00:00 UTC 2020

生物信息学

蛋白别名: Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; KOX1; NADPH oxidase 4; NOX 4; NOX-4; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4

基因别名: AI648021; KOX; KOX-1; NOX4; RENOX

UniProt ID: (Human) Q9NPH5, (Rat) Q924V1, (Mouse) Q9JHI8

Entrez Gene ID: (Human) 50507, (Rat) 85431, (Mouse) 50490

功能

nucleotide binding protein binding electron carrier activity NAD(P)H oxidase activity superoxide-generating NADPH oxidase activity oxygen sensor activity heme binding flavin adenine dinucleotide binding modified amino acid binding oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor oxidoreductase activity oxidase

参与通路

NOX4 Recombinant Rabbit Monoclonal Antibody (SY0214)

NOX4 Antibody (MA5-32090) in ICC/IF

产品信息

MA5-32090

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

功能检测 (Functional)

种属反应

已发表种属

宿主/亚型

Expression System

分类

类型

克隆号

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

NOX4 Recombinant Rabbit Monoclonal Antibody (SY0214)

NOX4 Antibody (MA5-32090) in ICC/IF

产品信息

MA5-32090

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

功能检测 (Functional)

种属反应

已发表种属

宿主/亚型

Expression System

分类

类型

克隆号

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#A2A2A2;}

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

RRID