Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
55116-1-AP
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M sodium bicarbonate/0.1M glycine, pH 7.3, with 50% glycerol, 0.1M glycine
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A and type B. Also see NPR3, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides and BNP, respectively).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ANP-A; ANPR-A; Atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor type A; atrionatriuretic peptide receptor A; GC-A; Guanylate cyclase A; natriuretic peptide A type receptor; natriuretic peptide receptor A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); NPR-A; testicular tissue protein Li 20
基因别名: ANPa; ANPRA; GUC2A; GUCY2A; NPR1; NPRA
UniProt ID: (Human) P16066
Entrez Gene ID: (Human) 4881
cGMP biosynthetic process
protein phosphorylation
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
G-protein coupled receptor signaling pathway
body fluid secretion
regulation of blood pressure
negative regulation of angiogenesis
negative regulation of cell growth
positive regulation of cGMP biosynthetic process
intracellular signal transduction
positive regulation of urine volume
positive regulation of renal sodium excretion
regulation of vasodilation
dopamine metabolic process
regulation of vascular permeability
negative regulation of smooth muscle cell proliferation
regulation of cardiac conduction
